Role of Metals in Neuronal Apoptosis: Challenges Associated with Neurodegeneration
نویسندگان
چکیده
منابع مشابه
HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration.
Despite the introduction of highly active antiretroviral therapy, dementia caused by human immunodeficiency virus-1 (HIV-1) infection remains a devastating and common neurological disorder. Although the mechanisms governing neurodegeneration during HIV-1 infection remain uncertain, the HIV-1 accessory protein, viral protein R (Vpr), has been proposed as a neurotoxic protein. Herein, we report t...
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Increased GSK-3 activity is believed to contribute to the etiology of chronic disorders like Alzheimer's disease (AD), schizophrenia, diabetes, and some types of cancer, thus supporting therapeutic potential of GSK-3 inhibitors. Numerous mouse models with modified GSK-3 have been generated in order to study the physiology of GSK-3, its implication in diverse pathologies and the potential effect...
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ژورنال
عنوان ژورنال: Current Alzheimer Research
سال: 2006
ISSN: 1567-2050
DOI: 10.2174/156720506778249399